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Product Detail

Melanotan II Peptides




Melanotan II is a cyclic heptapeptide analog of the alpha-melanocyte stimulating hormone (a-MSH), with the following molecular structure:

   It has been described to have superpotentmelanotropic activity in vitro. Its effect on tanning, like the effect of its similar peptide melanotan I, was also investigated (Dorr et al. 1996).

   The effects of melanotan II on the diet and food intake of the laboratory mice have also been investigated. It has been demonstrated that the central melanocortin (MC) has been activated by melanotan II when fed and induced in the mice. The six-day treatment through infusion has shown that melanotan II actually reduced the body weight and the adipose tissue in the viscera of the mice and suppressed the caloric intake of the organism. This has implications in clinical applications of the possible treatment to reduce carbohydrate or calorie intake especially for the overweight and the obese. Furthermore, the same study has also demonstrated that there was a sustained increase in the available oxygen consumption in obese animals. Melanotan also reduced the level of serum insulin and the cholesterol levels when compared with the control treatments. Furthermore, it has been suggested that melanotan actually lowers the level of acetylcholine Acaboxylase expression and even prevented the reduction of carnitine and palmitoltransferase I mRNA in muscle-type tissues by pair-feeding in the muscles of the obese rats. Moreover, the melanotan II actually increased the fat catabolism in the muscles and even improved the cholesterol metabolism (Li et al. 2004).

   Another study that has implications for clinical applications is the treatment of melanotan II and its effect of sexual motivation and enhanced erection in animals and humans. In a study conducted by Wessells et al. (2000), they have shown that melanotan II actually increased sexual desire and even concluded that melanotan II is a potent initiatot of penile erection in men especially with that of erectile dysfunction. This is the same with the findings of Dorr et al. (1996), which have shown that melatonan supplication resulted to nausea and yawning which appeared to be correlated with the onset of spontaneous penile erections.

   Other chemical activities of melanotan II when tested in vivo are inhibition of feeding, suppression of NPY orexigenic action and reduction in basal insulinaemia (Raposinho et al. 2003).

   Melanotan and melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (?-MSH) that tend to induce skin tanning. Unlike melanotan though, melanotan II has the additional effect of increasing libido. Melanotan II has aphrodisiac properties.

Active substance Melanotan II
Quantity 10
Unit Milligram
Quantity 1
Unit Vial
Presentation 10 milligrams per vial